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Faculty of medicine, Iran University of Medical sciences, Tehran, Iran , (metaleb@yahoo.com)
Abstract:   (65 Views)

Introduction: The prevalence of chronic obstructive pulmonary disease is increasing, and consequently its complications are growing. Several methods have been proposed for identifying chronic lung obstruction, including the use of a spirometric device and a review of pulmonary capacity. Meanwhile, the FEV3/FEV6 index has recently been introduced and has been shown to be effective in the diagnosis of obstructive lung disease. Therefore, in the present study, the importance of this index in identifying cases of chronic lung disease was first evaluated in Iranian patients.
Materials and Methods: In this cross-sectional study, patients who were suspected to chronic obstructive pulmonary disease which had positive clinical and laboratory symptoms after being informed and completing informed consent were evaluated. All patients were assessed with a spirometer and a body plethysmography, and FEV1, FEV3, FEV6 and FVC indices were measured. Then, based on the FEV1/FVC index,according to GOLD (Global initative for chronic lung disease) criteria the COPD cases were diagnosed if FEV1/FVC is less than 70%  and the patients were classified into two groups with and without COPD. In order to determine the efficacy of FEV3/FEV6, this index was measured and compared to FEV1/FVC in COPD diagnoses. The results were analyzed using independent t-test (for comparison of parameters with normal distribution) and the Mann-Whitney test (for comparing parameters with abnormal distribution) in SPSS version 23.        
Results: A total of 50 patients were examined, 42 of them were male and 8 were female. The mean age of the patients was 42.1±14 years. With the use of FEV1/FVC<70% in spirometer, 5 patients with COPD diagnosed. Also, 34 patients were diagnosed with Body-Plethysmography and RV> 80%, TLC> 80%, RV / TLC>120%, but with FEV3 / FEV6 <70%, none of the patients with COPD were detected.
Conclusion: The FEV3/FEV6 ratio is not a valuable diagnostic value for the detection of chronic lung obstruction. Although this index has had a positive diagnostic value in other countries, this issue has not yet been approved in Iranian patients and it seems that further evaluations are still needed.

Type of Study: Research | Subject: Special
Received: 2018/12/18 | Revised: 2019/04/27 | Accepted: 2019/04/22 | ePublished ahead of print: 2019/04/27

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