Volume 6, Issue 3 (5-2021)                   hrjbaq 2021, 6(3): 219-225 | Back to browse issues page


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Haghighi A H, Talebi S, Shahrabadi H. Effects of Exercise Training on Response of Covid-19- Like Vaccines in Older Adults; a Brief Report. hrjbaq. 2021; 6 (3) :219-225
URL: http://hrjbaq.ir/article-1-506-en.html
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran , (h.shahrabadi@gmail.com)
Abstract:   (429 Views)

The 2019 outbreak of coronavirus (covid-19) infections, which began in China in late 2019, is growing rapidly and the disease has spread worldwide. Studies have shown that the elderly have a higher risk of Covid-19 infection and death than others in the community. The aim of the present study was to investigate the effect of exercise on the response to Covid-19-like vaccines in the elderly. Aging is associated with a decline in the normal function of the immune system. Among prevention methods, vaccination is the main drug strategy to reduce the incidence and severity of viral diseases. It is noteworthy that the most vulnerable populations in the community who experience the most severe cases of Covid-19 disease are those who show a decrease in the effectiveness of the vaccine. Reasons for reduced flu vaccine reactions in the elderly may be due to immune aging and chronic disease. The data show that humoral and cellular immune responses after vaccination are low in the elderly. Decreased efficacy of the vaccine may be related to decreased antibody response. The response of cytotoxic T lymphocytes to viral infections and vaccination in the elderly is also impaired. Chronic exercise is also associated with several anti-influenza benefits, including reducing the risk of influenza and increasing the effectiveness of the vaccine. In active elderly, anti-influenza IgG and IgM and influenza-specific lymphocyte proliferation are higher than in sedentary individuals. Therefore, it is recommended that the elderly do training exercise to increase the effectiveness of the vaccines.

Author Contribution: Amir Hossein Haghighi developed original idea, Shahrbanoo Talebi contributed to article writing and Hadi Shahrabadi contributed to article writing and information collection.
Conflict of Interest/Funding/Supports: None.
Ethical Considerations: All ethical issues were considered in this study.
Applicable Remarks: To find newer ways to increase the effectiveness of the covid-19 vaccine in older adults.

Full-Text [PDF 1058 kb]   (33 Downloads)    
Type of Study: review | Subject: Special
Received: 2021/04/11 | Revised: 2021/09/4 | Accepted: 2021/07/5 | ePublished ahead of print: 2021/07/12 | Published: 2021/09/4

References
1. Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17(3):181-92. DOI: 10.1038/s41579-018-0118-9 PMID: 30531947
2. Vetter P, Eberhardt CS, Meyer B, Martinez Murillo PA, Torriani G, Pigny F, et al. Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series. mSphere. 2020;5(6). DOI: 10.1128/mSphere.00827-20 PMID: 33177214
3. Liu X, Wang J, Xu X, Liao G, Chen Y, Hu CH. Patterns of IgG and IgM antibody response in COVID-19 patients. Emerg Microbes Infect. 2020;9(1):1269-74. DOI: 10.1080/22221751.2020.1773324 PMID: 32515684
4. Talebi S, Nematshahi M, Tajabadi A, Khosrogerdi A. Comparison of Clinical and Epidemiological Characteristics of Deceased and Recovered Patients with COVID-19 in Sabzevar, Iran. Journal Mil Med. 2020;22(6):509-16.
5. Bahram ME, Pourvaghar MJ, Sadeh MR. Effect of 12 weeks of Chosen Pilates Exercise on the Quality of Iife of Healthy Nonathletic People. Tolooebehdasht. 2014;13(1):93-103.
6. Berg-Weger M, Schroepfer T. COVID-19 Pandemic: Workforce Implications for Gerontological Social Work. J Gerontol Soc Work. 2020;63(6-7):524-9. DOI: 10.1080/01634372.2020.1772934 PMID: 32501174
7. Dugan HL, Henry C, Wilson PC. Aging and influenza vaccine-induced immunity. Cell Immunol. 2020;348: 103998. DOI: 10.1016/j.cellimm.2019.103998 PMID: 31733824
8. Goodwin K, Viboud C, Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine. 2006;24(8):1159-69. DOI: 10.1016/j.vaccine.2005.08.105 PMID: 16213065
9. Wong GCL, Strickland MC, Larbi A. Changes in T Cell Homeostasis and Vaccine Responses in Old Age. Interdiscip Top Gerontol Geriatr. 2020;43:36-55. DOI: 10.1159/000504487 PMID: 32294651
10. Shahrabadi H, Haghighi AH, Talebi S. Effects of exercise training on improving the immune system of elderly people at the time of COVID-19 pandemic: A systematic review. Iranian Journal of War and Public Health. 2020;12(4):0-.
11. Song Y, Ren F, Sun D, Wang M, Baker JS, Istvan B, et al. Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review. Int J Environ Res Public Health. 2020;17(8). DOI: 10.3390/ijerph17082655 PMID: 32294922
12. Bachi AL, Suguri VM, Ramos LR, Mariano M, Vaisberg M, Lopes JD. Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals. Results Immunol. 2013;3:10-6. DOI: 10.1016/j.rinim.2013.01.001 PMID: 24600554
13. Zarei-Taher T, Kowsari A, Sheykhhasan M, Manoochehri H, Kalhor N, Naserpour L. [Introduce characteristic, types and functional mechanism of adjuvants as a biologic complement]. Journal of Fasa University of Medical Sciences. 2019;9(4):1758-73. http://journal.fums.ac.ir/ article-1-72-fa.html.
14. Negri E, Colombo C, Giordano L, Groth N, Apolone G, La Vecchia C. Influenza vaccine in healthy children: a meta-analysis. Vaccine. 2005;23(22):2851-61. DOI: 10.1016/j.vaccine.2004.11.053 PMID: 15780733
15. Bernstein E, Kaye D, Abrutyn E, Gross P, Dorfman M, Murasko DM. Immune response to influenza vaccination in a large healthy elderly population. Vaccine. 1999;17(1):82-94. DOI: 10.1016/s0264-410x(98)00117-0 PMID: 10078611
16. Gorse GJ, Campbell MJ, Otto EE, Powers DC, Chambers GW, Newman FK. Increased anti-influenza A virus cytotoxic T cell activity following vaccination of the chronically ill elderly with live attenuated or inactivated influenza virus vaccine. J Infect Dis. 1995;172(1):1-10. DOI: 10.1093/infdis/172.1.1 PMID: 7797897
17. Haq K, McElhaney JE. Immunosenescence: Influenza vaccination and the elderly. Curr Opin Immunol. 2014;29:38-42. DOI: 10.1016/j.coi.2014.03.008 PMID: 24769424
18. Keylock KT, Lowder T, Leifheit KA, Cook M, Mariani RA, Ross K, et al. Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly. J Appl Physiol (1985). 2007;102(3):1090-8. DOI: 10.1152/japplphysiol.00790.2006 PMID: 17095638
19. Kohut ML, Cooper MM, Nickolaus MS, Russell DR, Cunnick JE. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002;57(9):M557-62. DOI: 10.1093/gerona/57.9.m557 PMID: 12196490
20. Kohut ML, Arntson BA, Lee W, Rozeboom K, Yoon KJ, Cunnick JE, et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004;22(17-18):2298-306. DOI: 10.1016/j. vaccine.2003.11.023 PMID: 15149789
21. Woods JA, Keylock KT, Lowder T, Vieira VJ, Zelkovich W, Dumich S, et al. Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial. J Am Geriatr Soc. 2009;57(12):2183-91. DOI: 10.1111/j. 1532-5415.2009.02563.x PMID: 20121985
22. Long JE, Ring C, Drayson M, Bosch J, Campbell JP, Bhabra J, et al. Vaccination response following aerobic exercise: can a brisk walk enhance antibody response to pneumococcal and influenza vaccinations? Brain Behav Immun. 2012;26(4):680-7. DOI: 10.1016/j.bbi.2012. 02.004 PMID: 22386744
23. Ranadive SM, Cook M, Kappus RM, Yan H, Lane AD, Woods JA, et al. Effect of acute aerobic exercise on vaccine efficacy in older adults. Med Sci Sports Exerc. 2014;46(3):455-61. DOI: 10.1249/MSS.0b013e3182a75ff2 PMID: 23924918
24. Suzuki K, Tagami K. Voluntary wheel-running exercise enhances antigen-specific antibody-producing splenic B cell response and prolongs IgG half-life in the blood. Eur J Appl Physiol. 2005;94(5-6):514-9. DOI: 10.1007/ s00421-005-1378-4 PMID: 1595202.

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